Structure of PDB 6adq Chain Q Binding Site BS01

Receptor Information

>6adq Chain Q (length=312) Species: 1445611 (Mycolicibacterium smegmatis MC2 51)

WSDALALGWPTGITPEAKLNRELWIGSVIASFAVGAIVWGLIFWTSAFHR
KKATDTELPRQFGYNMPLELTLTVIPFLIISVLFYFTVVVQERMMHKDPN
PEVVIDVTAFQWNWKFGYQKIAFADGSFDYDGADPERKEAMTSRPEGKDE
HGIEKVGPIRGMTPEDRTYLNFDKIETLGTSSEIPVLVLPAGKRIEFVLN
SADVIHGFWVPEFLFKRDVLPEPKANNSDNVFQVSEIQQTGAFVGRCTEM
CGTFHAMMNFEVRVVEPNDFKAYIDQRNAGKTNAEALAAINQPPLAITTE
PFESRRGELVPQ

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 6adq Chain Q Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6adq An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): C277 H281 M284
• Binding residue (residue number reindexed from 1): C251 H255 M258
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6adq, PDBe:6adq, PDBj:6adq
• PDBsum: 6adq
• PubMed: 30361386
• UniProt: A0R057