Structure of PDB 5xtb Chain Q Binding Site BS01

Receptor Information
>5xtb Chain Q (length=385) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKT
YLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEIT
RLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIR
PGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVV
TAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYD
RYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESL
IHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPG
FAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
Ligand information
>5xtb Chain W (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KQDMPPPGGYGPIDYKRNLPRR
Receptor-Ligand Complex Structure
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PDB5xtb Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R166 L238 M241 Y245 S252 D256 E259 R338 L341 L348 P353
Binding residue
(residue number reindexed from 1)		R88 L160 M163 Y167 S174 D178 E181 R260 L263 L270 P275
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0048038 quinone binding
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:5xtb, PDBe:5xtb, PDBj:5xtb
PDBsum5xtb
PubMed28844695
UniProtO75306|NDUS2_HUMAN NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (Gene Name=NDUFS2)

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