Structure of PDB 5xjc Chain Q Binding Site BS01

Receptor Information
>5xjc Chain Q (length=1322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAEFVTQLACKYWAPHIKKKSPFDIKVIEDIYEKEIVKSRFAIRKIMLLE
FSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWEIFKKKPDH
FPFFFKHILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVDLIRSQVQQ
LISLPMWMGLQLARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQE
RRFLSQLIQKFISVLKSVPLSEPVTMDKVHYCERFIELMIDLEALLPTRR
WFNTILDDSHLLVHCYLSNLVRREEDGHLFSQLLDMLKFYTGFEINDQTG
NALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDTRESLVKF
FGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQI
QQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLR
NFNLFRLESTYEIRQDIEDSVSRMKPWQSGGVVFGGWARMAQPIVAFTVV
EVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPT
KPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIPRPNLRGESRTF
RVFLDPNQYQQDMTNTIQNGAEDVYETFNIIMRRKPKENNFKAVLETIRN
LMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLK
ASFPGHNVKVTVEDPALQPFRITFPVEAKTLIVEPHVIPNRGPYPYNQPK
RNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPE
QRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHEELETEKDFSRYGRV
NYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYI
SKVKNPDVTEVSTFFPFHEYFANAIFKGRSYEEDMEIAEGCFRHIKKIFT
QLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKY
DNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKN
MAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGN
LPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEY
VVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNK
VTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFAR
VSLFQNCFELTPAFSQLTARPLHLHIIPTETTRKNGERPSHEVQIIKNMP
QMANFVYNMYMHLIQTTHHYHQ
Ligand information
>5xjc Chain G (length=84) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggaaacggccuccgaacgguaagagccuagcauguagaacugguuaccuc
caggguuuccuugaugaugucauacuuauccugu
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xjc An Atomic Structure of the Human Spliceosome
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R557 R615
Binding residue
(residue number reindexed from 1)		R537 R590
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0034458 3'-5' RNA helicase activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016020 membrane
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xjc, PDBe:5xjc, PDBj:5xjc
PDBsum5xjc
PubMed28502770
UniProtO60306|AQR_HUMAN RNA helicase aquarius (Gene Name=AQR)

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