Structure of PDB 5oql Chain Q Binding Site BS01

Receptor Information

>5oql Chain Q (length=182) Species: 759272 (Thermochaetoides thermophila DSM 1495)

VDPDQTLKACKALLAHIKKAETPIWLTLTTKKHIHDSHRLQPGKIISVCL
ITADPQRFYKNGRVIDISHLKAKFKAYEAQRKLFSEHDVFLADTRIINRL
PKALGKTFYKTTTKRPIPVVLVHLSPSTNTAIKVGYANWEPEKLAANIET
VIRELVERFVPQKWQNVRNFYVKGPETAALPI

Ligand information

>5oql Chain 1 (length=1350)

ggggggauguccgggucgcccugggcaccucuccgcggcagcgcaagccg
uuucauacgucgccgcaaucgcgaggggcuccaagcggucgccggcgagc
accaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccgg
cgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccg
gggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagc
caccggggguaccuaccgguugucucggucgggccuccucuuggggcgcc
uaggcggugucuucgggucgcgugcagccucccguccucgccugccgaca
gcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagac
uggcgccggacgagcugcuggggcacgcggguacgcuagccgcacgauag
uuaccugguugauucuuagucauaugcuugucucaaagccaugcgucuaa
guauaagcaauuacagcgaaacugcgaauggcucauuaaaucaguuaucg
uuuauuugauaguauggauaaccgugguaauucuagagcuaauacaugcg
uauuuauuagggugauucauaauaacuucucgaaucgcacggccuugcgc
cggcgaugguucauucaaauuucugcccuaucaacuuucgacggcugggu
auuggccagccguggugacaacggguaagagaggagccugagaaacggcu
acuacauccaaggaagggcaggcgccaaauuacccaaucccgacacgggg
agguagugacaauaaauacugauacagggcuccgggucuuguaauuggaa
ugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucugg
ugccagcagccgcgguaauucccuccaauagcguauauugcucguaguug
aaccugauuaauagggacagucgggggcgucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaa
ggauguuuucauuaaucaggaacgauuagggaucggacggcguuuauuuu
ugacccguucggcaccuuacgauaaaucaaaauguuugggaguauggucg
caugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacug
acagagccagcgaguacucccuuggccgagaggcccggguaaacucuguc
gugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacg
ucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaagua

<<.<<<.<<<<<<<<....>>>>>>>>>>>.>.>.<<<<.<..>..>>>>
.........<<<<<<<.<<<<<..<<<<>>>>..>>>>>.>>.>>>>>..
..<..<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>
>>>>>...>>>>>..>........<<<<<<.<<<.....>>>.>>>>>>.
........................<<<...>>>.................
....<<<<<..<<<<<<<<.....>>>>>.>>>>>>>>.....<<<<<<.
..<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....
>>>>>>...........................<<<<.<<<<<<<..<.<
<<<..>>>>.>..>>>>>.>>.>>>><<<<.<.....>.>>>>.......
..................<..<<<<<<...<.<<..<<<<.<<<<<....
<<....<<.......>>...>>.>>......<<<.......<<<..<<..
<<....<<<.......<.<..<..<<<.....>>>..>.....>>....<
...<<<<<<.<......>.>>>>>>.....>...<<<<.<<<<.....>>
>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<..
.....>>>>>>>>>>>......>>>...>>><<.<<<..........>>>
.>>.<.<<<..>>>.>.>>>>>>........<<<...<<<<<...>>>>.
>>>>..>>...>.>....<<<<<<<<<<<<<...>>>>>>>>.>>>>>..
...<<..<...........>..>>.........<<<<<<.......<<<.
...>>>................>>>>>>..>>>>>>.>.<.<<...<<<.
<<.....>>.....<<<<<.<<...<<<<..<<<.<<<<<<.....<<<.
.....>>>........>>>>>>.>>>.......<<....>>...>>>>..
>>.>>>.>>....>>>...>>.>..<..<<..<<<<<<<<.<<<......
.>>>>>>>>>>>..>>.....<....>....>..................
..<<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<
<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>
..........>>>>>>....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>............>>>>>>.<<<<.<<......>>.>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5oql 3.2- angstrom -resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): T174 S236 S238 N240 T288 A289 A290
• Binding residue (residue number reindexed from 1): T111 S125 S127 N129 T177 A178 A179

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA

Cellular Component

• GO:0022625 cytosolic large ribosomal subunit
• GO:0030686 90S preribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5oql, PDBe:5oql, PDBj:5oql
• PDBsum: 5oql
• PubMed: 28967883
• UniProt: G0S7X0