Structure of PDB 5n61 Chain Q Binding Site BS01

Receptor Information

>5n61 Chain Q (length=389) Species: 559292 (Saccharomyces cerevisiae S288C)

TFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMKLIGHEAKLLFLKSFQF
ILKRQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTS
TISILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILQLYNKIALTCG
MIHFKEFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLT
LWERTDERHTGRVSNHAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLT
ESLTQRTTTSESIGRNIVKVVYPDKPTSSDYFQWSEEETLEFLKWMEKQF
LPTQTDQKIARRKLYKIFPLDSTHQLTFIEDLQERYAKQTPFFPPARKEA
IGRLLTHIASQLLVDFAISKEQLKDCISRIKNACLHRMN

Ligand information

>5n61 Chain T (length=41)

ttgtcttcaactgctttcgcgatgcatgcatgcatgcatgc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5n61 Structural Basis of RNA Polymerase I Transcription Initiation.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): F104 L154 Q155 H157
• Binding residue (residue number reindexed from 1): F44 L94 Q95 H97

Gene Ontology

Molecular Function

• GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0017025 TBP-class protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0001188 RNA polymerase I preinitiation complex assembly
• GO:0006360 transcription by RNA polymerase I
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I

Cellular Component

• GO:0000120 RNA polymerase I transcription regulator complex
• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0070860 RNA polymerase I core factor complex

External links

• PDB: RCSB:5n61, PDBe:5n61, PDBj:5n61
• PDBsum: 5n61
• PubMed: 28340337
• UniProt: P40992|RRN7_YEAST RNA polymerase I-specific transcription initiation factor RRN7 (Gene Name=RRN7)