Structure of PDB 5a8l Chain Q Binding Site BS01

Receptor Information
>5a8l Chain Q (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEF
GTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGK
EKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGA
LFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVA
ETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDI
SYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSH
FTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGF
GGIGGILRYRVDFQGMEYQGGDDEFFDLDDY
Ligand information
>5a8l Chain A (length=253) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugacgugcaaaucaaucgaaccaucgcaggaagguggccauggaagucgg
aauccgcuaaggaguguguaacaacucaccugcgcaauuaguaacuauga
cuugccucguccgcauaaaccaagaagacccucuggggcggaccacaggg
auaacuggcuuguggccaagcguucauagcgacuuuuugauccuucgaug
ucggcuuguucagaacgugacuggguuuagaacagguuaguuuuaacgag
agg
.<<........>>............<<<<<..<....<<.........>>
....>..........<<......>>...>>>>>......<<<.......>
>>...................<<......<<<<<.....>>.....>>>.
......<<.<.<.<.....<<.......>>...>...>>.>.>.......
<.<<................>>..>....<.......>....>>......
...
Receptor-Ligand Complex Structure
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PDB5a8l Structure of a Human Translation Termination Complex.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R47 E55 N121 T122 S123 G153 N164 L176 K178 K179 H180 G181 R182 Q185 L188 R189 F190 R192 H199 R203 S229 A230 R245 S257 N265 S295 D297 G315 K384 F385 G386 R414 Y415 F432 D436
Binding residue
(residue number reindexed from 1)		R41 E49 N115 T116 S117 G147 N158 L170 K172 K173 H174 G175 R176 Q179 L182 R183 F184 R186 H193 R197 S223 A224 R239 S251 N259 S289 D291 G309 K378 F379 G380 R408 Y409 F426 D430
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0005515 protein binding
GO:0008079 translation termination factor activity
GO:0016149 translation release factor activity, codon specific
GO:0043022 ribosome binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:0006479 protein methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a8l, PDBe:5a8l, PDBj:5a8l
PDBsum5a8l
PubMed26384426
UniProtP62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)

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