Structure of PDB 4u67 Chain Q Binding Site BS01

Receptor Information

>4u67 Chain Q (length=93) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

SHYDILQAPVISEKAYSAMERGVYSFWVSPKATKTEIKDAIQQAFGVRVI
GISTMNVPGKRKRVGRFIGQRNDRKKAIVRLAEGQSIEALAGQ

Ligand information

>4u67 Chain X (length=2667)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaauc
aagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguagg
cgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggacca
ccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugag
ggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccg
uggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauu
gaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaa
cggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucggg
cuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggg
gggcggaggaccgaaccggugccugcugaaacagucucggaugaguugug
uuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaa
auguauugagguacagccucggauguugaccauguccuguagagcacuca
caaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccggga
gugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagac
caucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucguc
gcauagacagccaggagguuggcuuagaagcagccaccaagagugcguaa
uagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagug
aucuaccgaagcuauggauucaacucgccgaguugucugguaggggagcg
uucaguccgcggagaagccauaccggaaggagugguggagccgacugaag
ugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgcc
guaaggacaaggguuccuggggaagggucguccgcccagggaaagucggg
accuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuc
cugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugc
caagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaa
aucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaa
guuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugau
ugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggc
gcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuuc
ggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccagg
cgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacgua
uagggugugacgccugcccggugccggaaggucaaguggagcggugcaag
cugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucg
gguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaa
cgagggacucggugaaauugaauuggcuguaaagaugcggccuacccgua
gcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauu
cggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggac
cgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacg
gaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgc
aaagguagaagguggcuugacugcgagacugacacgucgagcagggagga
aacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaa
cggauaaaaguuaccccggggauaacaggcugaucucccccgagagucca
uaucggcggggagguuuggcaccucgaugucggcucgucgcauccugggg
cugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcg
agcuggguucagaacgucgugagacaguucggucucuauccgcuacgggc
gcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaac
ggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcua
uguccggaacggauaaccgcugaaagcaucuaagcgggaagccagcccca
agaugaguucucccacugcagguaagacucccggaagaccaccggguuaa
gaggccaggcgugcacgcauagcaauguguucagcggacuggugcucauc
agucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<....
..<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<.....
..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>
>........<<<<<<<<.........>>>>>>>>......<<<<<..(((
(>>>>>..>>>......>>.>>>>>>.>>..............<<....>
>....>>.........<<<<....>>>>.............>....>>>>
>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<...
.....>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>
>...>>>...<<....>>...<<......>>.........>>>>>>>>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>
>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<
.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.
>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<
<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<
<........<<<<<......<<<<.......>>>>.........<<....
..>>...>>>>>....>>>>>>>>>.>>..........)))......>>>
>>>.>>>...>>>>>>><..<<<<<<...>>>>>>..>....>>>>>><.
<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.
.>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>
>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<
<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<...
..>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>...
.>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>
>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..
>......>>>>><<<<<<<<...>>>>>>>>............<<<<<<<
<<..<<...........>>..<<<<<<<.....<<<.....>>>......
.>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>
>>>>...>>...>>>>>>>>..>>>>........<...........<<<<
<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>
>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<
<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<
<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.>>>>>...
.>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<..
.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<..
..>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.....
........>>>>..>>>>>>.......<<<<...<<<<<<...<<.....
..>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<
<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>..
.>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>.
...<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<
<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>
.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.
......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....
<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...
>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4u67 The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.
• Resolution: 3.65 Å
• Binding residue (original residue number in PDB): S13 E14 K32 T34 K35 R49 S54 M56 N57 K61 R62 R64 F68 I69 G70 Q71 R72 N73 K77 I79
• Binding residue (residue number reindexed from 1): S12 E13 K31 T33 K34 R48 S53 M55 N56 K60 R61 R63 F67 I68 G69 Q70 R71 N72 K76 I78

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u67, PDBe:4u67, PDBj:4u67
• PDBsum: 4u67
• PubMed: 28689968
• UniProt: Q9RXK0|RL23_DEIRA Large ribosomal subunit protein uL23 (Gene Name=rplW)