Structure of PDB 4s2t Chain Q Binding Site BS01

Receptor Information

>4s2t Chain Q (length=612) Species: 6239 (Caenorhabditis elegans)

MTALEKLAKLRSLFHSERVLALTSSKPMVAYLLPSTDAHHSEYLADYDFR
VKFLSGFSGSNAYVVVTDREALLWTDGRYFTQAGNQLDSNSWKLMKQGQP
DSITVVDWLVRELERGSVIGFDPTLSTFDAGSKTFKRLKAAGLQPVSIPG
NLVDEFWTDRPRLAGEPVVVLDVEDTGLTTSKKVENLREKLKQKKCDAAV
FTLLDDVMWLLNIRGSDIPYNPLAYSYLFVAMREIHVFIDNEKLDEKSRA
HFHKSNVSIHPYGEVYSWISNWLKAKEASKEPHMVYLTPETNYAIGSIIG
EENSMVDTSLVQTAKATKNDHEMQGMRNSHLRDSAALVEFLCWLEKELLS
GKRYTEIELADKIDHLRSLQDKYVTLSFDTISAVGDHAALPHYKPLGESG
NRKAAANQVFLLDSGAHYGDGTTDVTRTVWYTNPPKEFILHNTLVLKGHI
NLARAKFPDGIYGSRLDTLTRDALWKLGLDFEHGTGHGVGHYLNVHEGPI
GIGHTGGELHASQVLTIEPGFYAKEKYGIRIENCYETVEAVVMSKAQNFL
TFKSLTLVPIQTSIVDKSLLIEEEINWLNQYHARVLKEVGEHLQKRGKTD
ELKWLAEACKPI

Ligand information

>4s2t Chain B (length=4)

tPPA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4s2t Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): Y43 R78 F378 I381 H392 K394 D424 H483 G484 G486 H487 H496 E522 E536
• Binding residue (residue number reindexed from 1): Y43 R78 F378 I381 H392 K394 D424 H483 G484 G486 H487 H496 E518 E532

Enzymatic activity

• Enzyme Commision number: 3.4.11.9: Xaa-Pro aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008270 zinc ion binding
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4s2t, PDBe:4s2t, PDBj:4s2t
• PDBsum: 4s2t
• PubMed: 25905034
• UniProt: O44750|XPP_CAEEL Xaa-Pro aminopeptidase app-1 (Gene Name=app-1)