Structure of PDB 3rj1 Chain Q Binding Site BS01

Receptor Information
>3rj1 Chain Q (length=159) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGQALDAVRMRLAQLTHSLRRIRDEMSKAELPQWYTLQSQLNVTLSQLVS
VTSTLQHFQETLDSTVVYPLPKFPTTSHESLVTTLLRKKNIPEVDEWMKY
VRETSGVTTALLKDEEIEKLLQQDREITNWARTTFRNEYGKHDPFNVDDV
LKFTFTGEK
Ligand information
Ligand IDSE
InChIInChI=1S/H2Se/h1H2
InChIKeySPVXKVOXSXTJOY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[SeH2]
CACTVS 3.341[Se]
FormulaSe
NameSELENIUM ATOM
ChEMBLCHEMBL1235891
DrugBank
ZINC
PDB chain3rj1 Chain Q Residue 325 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3rj1 Architecture of the Mediator head module.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		E53 M54
Binding residue
(residue number reindexed from 1)		E25 M26
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
GO:0030674 protein-macromolecule adaptor activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rj1, PDBe:3rj1, PDBj:3rj1
PDBsum3rj1
PubMed21725323
UniProtP38304|MED8_YEAST Mediator of RNA polymerase II transcription subunit 8 (Gene Name=MED8)

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