Structure of PDB 2fk0 Chain Q Binding Site BS01

Receptor Information

>2fk0 Chain Q (length=322) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1)))

GDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKP
LILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYE
ELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVW
LIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYIS
VGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIA
PEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTI
GECPKYVKSNRLVLATGLRNSP

Ligand information

• Ligand ID: BMA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-RWOPYEJCSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-mannopyranose;
  beta-D-mannose;
  D-mannose;
  mannose
• ZINC: ZINC000003830679
• PDB chain: 2fk0 Chain X Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fk0 Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus.
• Resolution: 2.95 Å
• Binding residue (original residue number in PDB): D53 G55 V56 K57 N276 N278
• Binding residue (residue number reindexed from 1): D44 G47 V48 K49 N274 N276
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0046789 host cell surface receptor binding

Biological Process

• GO:0019064 fusion of virus membrane with host plasma membrane

Cellular Component

• GO:0019031 viral envelope

External links

• PDB: RCSB:2fk0, PDBe:2fk0, PDBj:2fk0
• PDBsum: 2fk0
• PubMed: 16543414
• UniProt: Q1KHJ8