Structure of PDB 8q1b Chain P Binding Site BS01

Receptor Information

>8q1b Chain P (length=182) Species: 4896 (Schizosaccharomyces pombe)

SPEMPDFSEYQTKSTGDRSRVISYAMVGTMGALTAAGAQATVHDFLASWS
ASADVLAMSKAEVDLSKIPEGKNLVVKWQGKPVFIRHRTPEEIQEANSVD
ISTLRDPQADSDRVQKPEWLVMIGVCTHLGCVPIGEAGDYGGWFCPCHGS
HYDISGRIRRGPAPLNLAIPAYTFEGSKIIIG

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 8q1b Chain P Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q1b Structure and function of the S. pombe III-IV-cyt c supercomplex.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): C172 H174 C177 C191 C193 H194
• Binding residue (residue number reindexed from 1): C126 H128 C131 C145 C147 H148
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.8: quinol--cytochrome-c reductase.

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045275 respiratory chain complex III

External links

• PDB: RCSB:8q1b, PDBe:8q1b, PDBj:8q1b
• PDBsum: 8q1b
• PubMed: 37939086
• UniProt: Q09154|UCRI_SCHPO Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=rip1)