Structure of PDB 8p2i Chain P Binding Site BS01

Receptor Information
>8p2i Chain P (length=48) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEAVYRCFKCGREVKLDLSITRDLRCPYCGSKILYKPRPKVPRRVKAI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p2i Chain P Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8p2i Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C8 C27
Binding residue
(residue number reindexed from 1)		C7 C26
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p2i, PDBe:8p2i, PDBj:8p2i
PDBsum8p2i
PubMed38709902
UniProtQ8TZI3|RPO12_PYRFU DNA-directed RNA polymerase subunit Rpo12 (Gene Name=rpo12)

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