Structure of PDB 8oeq Chain P Binding Site BS01 |
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| >8oeq Chain B (length=1712)
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uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaa
uucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguau
uuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaa
cuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucug
cccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggg
uaacggggaauaaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacgg
ggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguac
aauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguua
aaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagc
cgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggac
guuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucggggguaucaguauucaguugucagaggugaaauucuuggauu
uacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacg
caaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcug
guauagucacuucuuagagggacuaucgauuucaagucgauggaaguuug
aggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcg
cuacacugacggagccagcgaguauaagccuuggccgagaggucugggaa
aucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcuc
uucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuac
gucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcu
uagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuug
gucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucau |
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..........<<.....<..<<....
...>>..>......>>........<<<<<..<<....>>..>>>>><...
<<<<<<.......((((((.<<<....>>>..............>>>>>>
.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.
>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>
>..>>>..>....>.>.....<<<<...<...>...>>>>......<<..
<...........>..>>.........<<<<<((......<<<<.....<<
..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.
....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>
>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<...
....>..<<<....>>>....>>......>>.>>..>>>.........<<
<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>
>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......
<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<
<..<<<.<<<<<<......<<........>>..........<<<<<....
..<<<<<........<<.<<<........>>>.>>......>>>>>...<
<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>
>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>..
..>>.......>>>>>>>...........<<<<<<..........>>>>>
>..........>>>>>>....<<<<<<<<.......>>>>>>>>......
>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<
.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>
>>>>>....... |
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| PDB | 8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement |
| Resolution | 3.3 Å |
Binding residue
(original residue number in PDB) | G2 R3 M4 H5 K9 G10 I11 S12 S14 A15 P17 R20 P47 S48 G51 V52 R55 S61 K64 K70 I71 L72 R73 K76 D87 Y90 K94 S97 V98 H101 N105 K107 D108 K109 D110 K112 F113 R114 I116 L117 S120 R121 R124 R127 Y128 |
Binding residue
(residue number reindexed from 1) | G1 R2 M3 H4 K8 G9 I10 S11 S13 A14 P16 R19 P46 S47 G50 V51 R54 S60 K63 K69 I70 L71 R72 K75 D86 Y89 K93 S96 V97 H100 N104 K106 D107 K108 D109 K111 F112 R113 I115 L116 S119 R120 R123 R126 Y127 |
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