Structure of PDB 8i0s Chain P Binding Site BS01

Receptor Information
>8i0s Chain P (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFRRELEERERAAAREK
NRDRKVKRRWDDDVVFKNCAKGVDDQKKDKRFVNDTLRSEFHKKFMEKYI
K
Ligand information
>8i0s Chain B (length=98) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccg
uggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua
.<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...
>>>>>>>>>>>................<<<<<<<<....>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8i0s Molecular Basis for the Activation of Human Spliceosome
Resolution4.2 Å
Binding residue
(original residue number in PDB)		S32 R33 P36 S37 H38 T39
Binding residue
(residue number reindexed from 1)		S8 R9 P12 S13 H14 T15
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005739 mitochondrion
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0s, PDBe:8i0s, PDBj:8i0s
PDBsum8i0s
PubMed39068178
UniProtQ9P013|CWC15_HUMAN Spliceosome-associated protein CWC15 homolog (Gene Name=CWC15)

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