Structure of PDB 8etc Chain P Binding Site BS01

Receptor Information

>8etc Chain P (length=169) Species: 4896 (Schizosaccharomyces pombe)

VRYSASPALETKCAKARGAYLRTHFKNSREVAFTINGMSLKKAFIFLDNV
KEHKQAVPFRRFNGGVGRTAQGKEFGVTQARWPVKSVKFFYDLLKNAEAN
AEAKGLDMDKLIIKHVQVNAAPKQRRRTYVTAYLSSPSHIEIIVAEEEET
VSRVSLKQGAKARNLAARK

Ligand information

>8etc Chain 1 (length=2140)

auuugaccucaaaucagguaggacuacgcgcugaacucaauaagcgcagg
aaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcuc
aaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaa
gaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacg
ucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaa
gcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucua
aagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaa
gaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaa
agggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaag
aauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggg
gacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaa
uggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuuggg
ugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccu
ggcgugcaccaucgaccgacccggaaggguuugaguaagagcauagcugu
ugggacccgaaagauggugaacuaugccugaauagggugaagccagagga
aacucugguggaggcucguuuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguuccugccgaaggcagaaacucagaucaguuuuaugu
guaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucag
acaccagaaaagguguuaguucaucuagacagcaggacgguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucca
ugugaacagcaguuggacauggguuagucgauccuaagagauagggaagc
uccguaugaaaaucgaaagggaauccgguuaauauuccggaaccagaagg
uggaacacggcaacguaaaugaaguuggagacgucggcgggagcccuggg
aagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuaucc
ggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccg
gugcgcucucgacggccuugaaaauccaacggaaguuucacaucuggucg
uacucauaaccgcagcaggucuccaaggugagccucuaguugauagaaca
auguagauaagggaagucggcaaaaugggaaucgauucccacugucccua
ucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucag
cgggguggcuuguggcagccaagcgcgacguugcuggcucuuccuaucau
accgaagcagaauucgguaagcguuggacccacuaauagggagcuggguu
ccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagagga
accguugauucagaucauugguauuugcggcugccugacaaggcaaugcc
gcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauc
cgugccagaaagcgacgauuguauaaaaauagaggucucuccuguaucgu
agaagaugggcgaugguugaugaaacggaaguguuuuauugacuugucca
ugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauug
uaagcagcugcugagauuaagccuuuguucccaagauuug

..........................<<<<<<..........>>>>>.>.
........<<....>>..<<<<<......<<.>>.....>>>>>..<<<.
.<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....
<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.(
(......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>
>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>.
.>>>..................................<<....>>....
...........<<<<....>>>>...........................
.......<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......
.<<<<<<<......<...>......>>>>>>>.......>>>>>.>>>>>
>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<
<.......>>>>>..>>>...<<....>>........<<<<..<<<<<..
>>>>>...>>>>..<<<<<<<<....>>>.>>>.>>....>>>>>>.>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<..
..>>>>>>>.....>>>.>>>>>>>>>...<<.......>>......>>>
>>>......>.>>..<<<<<<....<<<<<<<<<<...<<<.<<<<<<..
>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<
..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.....
....>>....>>.........<<......>>...>>>>>...>>>>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<....
.<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....
>>>.........>>....>>...<<<<<........>>>>>))<<<<..<
<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<
<<<<<....(..>>>>>>....<<<<<...<<<<<<....<<<.....>>
>....>>>>>>.....>>>>>.....<<<<<<<<.....>>>>>>>>>>>
>...>>>>>>>.>>>>........>>>>>>........>>>.>>>>>>>>
..>>.....<<......>>>>>>>.<<<<..>>>>..>>>>..<<<<...
..<<<<<<<.<<.........<.....<<<<<<>>>>>>...>..>>.>>
>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<
..<<.........<<<<<<...<..>...>>>>>><<<..<<<<<..<.<
<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>>>>.....
.>>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<..............
...>>>>>.><<<<<...<<<<...<<<<<<<<<<.)....>>>>..>>>
>>>..>>>>..>>>>>.<<<<....<<<<...........>>>>....>>
>>.>>>>....>>>>>>>>...<<.......<<<<..>>>>....>>...
.....<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>
>.........<<<<<.<.............>.....<<<<<<<<<.<<<.
...<<<..>>>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8etc Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R3 K16 R18 Y21 R23 H25 F26 K27 R30 K55 R62 F63 G65 G66 G68 R69 T70 A71 K74 T79 Q80 R82 W83 P84 V85 K86 N97 A100 N101 H116 Q118 V119 K124 R127 Y130 V136 T137 A138 Y139 L140 S141 R166 S168 L169 K170 K174 R176 N177 R181
• Binding residue (residue number reindexed from 1): R2 K15 R17 Y20 R22 H24 F25 K26 R29 K54 R61 F62 G64 G65 G67 R68 T69 A70 K73 T78 Q79 R81 W82 P83 V84 K85 N96 A99 N100 H115 Q117 V118 K123 R126 Y129 V130 T131 A132 Y133 L134 S135 R153 S155 L156 K157 K161 R163 N164 R168

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8etc, PDBe:8etc, PDBj:8etc
• PDBsum: 8etc
• PubMed: 36423630
• UniProt: O14339|RL17A_SCHPO Large ribosomal subunit protein uL22A (Gene Name=rpl1701)