Structure of PDB 8asc Chain P Binding Site BS01

Receptor Information

>8asc Chain P (length=531) Species: 9606 (Homo sapiens)

SGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDE
IALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQ
QADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHS
LKKCDISLQFFLPFSLGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVM
ISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIA
AYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQ
GFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVL
KVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHI
KHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMS
LAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHI
WNMLNPPAEVTTKSQIPLSKIKTLFPLIEAK

Ligand information

>8asc Chain Q (length=20)

cggatcgagggcccgatatc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
• Resolution: 2.95 Å
• Binding residue (original residue number in PDB): R271 T275 D398 R400 R431 R486
• Binding residue (residue number reindexed from 1): R259 T263 D386 R388 R419 R474

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0003684 damaged DNA binding
• GO:0042162 telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0006310 DNA recombination

Cellular Component

• GO:0005634 nucleus
• GO:0043564 Ku70:Ku80 complex

External links

• PDB: RCSB:8asc, PDBe:8asc, PDBj:8asc
• PDBsum: 8asc
• PubMed: 37256950
• UniProt: P13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)