Structure of PDB 7znk Chain P Binding Site BS01
Receptor Information
>7znk Chain P (length=367) Species:
9606
(Homo sapiens) [
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LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAMGKTAVFVLATL
QQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSI
KKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQ
LDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVKLT
LHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLV
EQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNI
AFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFE
VNISELPDEIDISSYIE
Ligand information
>7znk Chain 2 (length=3) [
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uuu
...
Receptor-Ligand Complex Structure
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PDB
7znk
mRNA recognition and packaging by the human transcription-export complex.
Resolution
3.9 Å
Binding residue
(original residue number in PDB)
T122 R123 G150 G151 T172 P173 G174 R175 D206
Binding residue
(residue number reindexed from 1)
T68 R69 G96 G97 T118 P119 G120 R121 D152
Enzymatic activity
Enzyme Commision number
3.6.4.13
: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0003723
RNA binding
GO:0003724
RNA helicase activity
GO:0003729
mRNA binding
GO:0004386
helicase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008186
ATP-dependent activity, acting on RNA
GO:0016787
hydrolase activity
GO:0016887
ATP hydrolysis activity
GO:0017070
U6 snRNA binding
GO:0030621
U4 snRNA binding
GO:0042802
identical protein binding
GO:0043008
ATP-dependent protein binding
Biological Process
GO:0000245
spliceosomal complex assembly
GO:0000398
mRNA splicing, via spliceosome
GO:0006397
mRNA processing
GO:0006405
RNA export from nucleus
GO:0006406
mRNA export from nucleus
GO:0008380
RNA splicing
GO:0010501
RNA secondary structure unwinding
GO:0051028
mRNA transport
Cellular Component
GO:0000346
transcription export complex
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005681
spliceosomal complex
GO:0005687
U4 snRNP
GO:0005688
U6 snRNP
GO:0005737
cytoplasm
GO:0016607
nuclear speck
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:7znk
,
PDBe:7znk
,
PDBj:7znk
PDBsum
7znk
PubMed
37020021
UniProt
Q13838
|DX39B_HUMAN Spliceosome RNA helicase DDX39B (Gene Name=DDX39B)
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