Structure of PDB 7xd9 Chain P Binding Site BS01

Receptor Information

>7xd9 Chain P (length=616) Species: 11060 (dengue virus type 2)

ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIF
KLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQL
IRQMEGEGVFKSIQHEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDR
FASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRV
LVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLR
LAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSL
IGNEEYTDYMPSMKRF

Ligand information

>7xd9 Chain Q (length=12)

acgauuauaucc

............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xd9 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Resolution: 2.58 Å
• Binding residue (original residue number in PDB): K402 A408 M455 K457 I474 Y476 R482 N493 G509 G602 Q603 V604 W803 V812 R815
• Binding residue (residue number reindexed from 1): K135 A141 M188 K190 I207 Y209 R215 N226 G242 G333 Q334 V335 W530 V539 R542

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd9, PDBe:7xd9, PDBj:7xd9
• PDBsum: 7xd9
• PubMed: 36577062
• UniProt: Q91H74