Structure of PDB 7xd8 Chain P Binding Site BS01

Receptor Information
>7xd8 Chain P (length=611) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASS
MVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEG
TKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKW
KSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAK
GSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYIL
RDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIF
KLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQL
IRQMEGEGVFEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASAL
TALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPC
RNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANA
ICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWMEDKT
PVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEE
YTDYMPSMKRF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		A408 I474 Y476 R482 N493 H513 G602 Q603 V604 W803 M804 V812
Binding residue
(residue number reindexed from 1)		A139 I205 Y207 R213 N224 H244 G333 Q334 V335 W525 M526 V534
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
PDBsum7xd8
PubMed36577062
UniProtQ91H74

[Back to BioLiP]