Structure of PDB 7ttw Chain P Binding Site BS01

Receptor Information

>7ttw Chain P (length=44) Species: 1280 (Staphylococcus aureus)

VKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA

Ligand information

>7ttw Chain 1 (length=2690)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaaca
ugggugauaagguccguguucgaaagggaaacagcccagaccaccagcua
aggucccaaaauauauguuaaguggaaaaggauguggcguugccacagag
ugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugug
gauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcau
gaucguaaggacauguggagcgcuuagaagugagaaugccggugugagua
gcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagag
gaaggcucguccgcucuggguuagucggguccuaagcugaggccgacagg
cguaggcgauggauaacagguugauauuccuguaccaccuauaaucguau
cgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgu
cuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuuc
gagucguugauuucacacugccgagaaaagccucuagauagaaaauaggu
gcccguaccgcaaaccgacacagguagucaagaugagaauucuaagguga
gcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgg
gagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauag
gcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggu
gauguauaggggcugacgccugcccggugcuggaagguuaagaggagugg
uuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccc
gcacgaaaggcguaacgauuugggcacugucucaacgagagacucgguga
aaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagac
cccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccg
caccacuuaucguggugggagacagugucaggcgggcaguuugacugggg
cggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaug
guuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgag
accuacaagucgagcagggucgaaagacggacuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucga
ugucggcucaucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacauaccucugguguaccaguugucgugc
caacggcauagcuggguagcuauguguggacgggauaagugcugaaagca
ucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaa
gaucccucaaagaugaugagguuaauagguucgagguggaagcaugguga
cauguggagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<......
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>........>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<.>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<.<.<<........
>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<
<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......
<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>
>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<
<...<<<<....<<<<...<<...<....<.<<<.........>>>.>.<
....<<<<...<<<........>>>...>>>>.....>.....<....>.
.......>....>>...>>>>.........>>>>..>>......>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>.
.<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>
.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>
.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<
<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
...>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<..>.>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<..
...>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<...
...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....
<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....
>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttw A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): V2 K3 R4 T5 Y6 Q7 P8 K10 R11 K12 H13 S14 K15 V16 H17 F19 R20 K26 N27 R34 R35 R36 K38 R40 K41
• Binding residue (residue number reindexed from 1): V1 K2 R3 T4 Y5 Q6 P7 K9 R10 K11 H12 S13 K14 V15 H16 F18 R19 K25 N26 R33 R34 R35 K37 R39 K40

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttw, PDBe:7ttw, PDBj:7ttw
• PDBsum: 7ttw
• PubMed: 35736238
• UniProt: Q2FUQ0|RL34_STAA8 Large ribosomal subunit protein bL34 (Gene Name=rpmH)