Structure of PDB 7pwg Chain P Binding Site BS01

Receptor Information
>7pwg Chain P (length=154) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKYAFKSDNLLVGKSRRDGVKASFKNTYSTCRAIKGMGVKRAFAYLDNVL
NHKEIVPFFKFYKGVGRHSQARGSGTDKGRWPEKSVVVVKDILKQAVSNA
KHAHKKEEDELYVISYCVNRARGRRRRTFRAHGRISKYESQPCHVELIVG
PKPL
Ligand information
>7pwg Chain 1 (length=2450) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcgccccggaggacugagggggagacggguuccgcggcgccugc
aucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaagg
ggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcg
ggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcg
ccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggg
gggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggg
gcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuag
cgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccu
cgggaaaaggaguggcucugacggggucagaacuggaacggacgcgggga
ucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcu
ggcgcgacgugauuucugcccagugccagaccgucaccgugaagcgaucc
gccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaa
augccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccc
acugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgag
ggccggccagcggggcaagaagacccuuuugagcuugacuccagcccggg
ccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccg
ggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcg
ucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaag
cccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggcc
uaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguu
accacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggc
uuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgc
ggaagcgucggauuguucacccguucaagggaucgugagcuggguuuaga
ccgucgugagacgguuaguuuuacccuacuggccccggggccagagcacg
gcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguug
cccgccggggcaggaccgcgcgcccgggcccgggggccuggcgcugccgc
cucuaaagcgccaccccccccuccggccccgccgcccgcgccccagcccc
gugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggc
gccccuguacggcgagggcgcguucgcccggggggcgcgccgcgggcgcg
......................<<<<<<.....<<....>>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<.....<<<<<......>>
>>>((......<<<.....))>>>....>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<..
..<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<...
....>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<
<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<
<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<....
.....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>
>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>
>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>
....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<.
.>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>...
...>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>
>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<....
.......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>
..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>
>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<
<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>
>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>.
.<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>
>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))
).......(((((.(((((.>>>>>>))))))))))..........]]]]
..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>
>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<
<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<
<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<
<<<....>>>>>..>>>>>....>.>.>>>>>.<<<...<<<<<<.....
......>>>>>>...>>>..>>>.>>>>>>...<.<<<............
.................>>>.>...<<.<<<<.......>>>>..<<<<<
<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwg Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)
Y4 K15 S16 R17 R18 S24 K26 Y29 K36 K61 F62 Y63 K64 G65 G67 R68 H69 S70 Q71 R73 G74 D78 R81 W82 E84 K85 Q96 N100 H103 Y117 C118 V119 R125 R127 F130 R131 A132 H133 G134 I136 S137 K138 Y139 E140 S141 Q142
Binding residue
(residue number reindexed from 1)
Y3 K14 S15 R16 R17 S23 K25 Y28 K35 K60 F61 Y62 K63 G64 G66 R67 H68 S69 Q70 R72 G73 D77 R80 W81 E83 K84 Q95 N99 H102 Y116 C117 V118 R124 R126 F129 R130 A131 H132 G133 I135 S136 K137 Y138 E139 S140 Q141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7pwg, PDBe:7pwg, PDBj:7pwg
PDBsum7pwg
PubMed35100413
UniProtA8BE76

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