Structure of PDB 7ohp Chain P Binding Site BS01

Receptor Information
>7ohp Chain P (length=98) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQVLWPAKSVK
FVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKESSPSHIELVVTE
Ligand information
>7ohp Chain 1 (length=1567) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaacucaauaagcggagg
aaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggcaaaag
cucaaauuugaaaucugguaccucggugcccgaguuguaauuuggagagg
gcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucaua
gagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccu
ucgaagagucgaguuguuuaugcagcucuaagugggugguuccaucuaaa
gcuaaauauuggcgagagaccgauagcgaacaguacagugauggaaagau
gaaaagaacuuugagagagugaaaaaguacgugaaauuguugaaaggaag
ggcauuugaucagacaugguguuuuguucucgcauuucacugggccagca
ucaguuuugguggcaggauaaauccauaggaauguagcuugccgguaagu
auuauagccugugggaauacugccagcugggacugaggacugcgacguaa
gucaaggaugcuggcaaaugguuauaugccgccgucuugaaacacggacc
aaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcgua
augaacgagguuggggccucgaagaggugcacaaucgaccgauccugagg
auggauuugguaagagcauagcuguugggacccgaaagauggugaaacca
ucuaguacugguuccugccgaaguuucccucaggauagcagaagcucguu
caguuuuauguaagaaugaagcuuuuagugggccauuuuugggcagaacu
ggcgaugcgggaugccgaacguagaguuaaggugccggaauacacgcuca
agacaaaagguguuaguucaucuagacagccggacggugccauggaaguc
ggaaccgcaggaguguguaacaacucaccggccgaaugaacuagcccugg
gcgcucaagcguguuaccuauacucuaccgucaggguugauaugcccuga
cgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgg
gucgaacggccucuagugcagaucuuggugguaguagcagcgaaaccaca
gccaaggcgggaaucagcauaccgaagcagaauucgguaagaugaauguu
accgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaa
uugguuugcggcugucugaucaggcagccgcgaagcuacauccgcuggau
uauggcugaacccucuaagucagauccaugcuagaacgcggugauuucuu
ugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgc
ugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggug
cuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguau
acgacuuagauguacaacgggguauuguaagcaguacugcugagauuacc
uuuguugucugauuugu
..........................<<<<<<..........>>>>>.>.
........<<....>>...<<<<......<<....>>.....>>>>...<
<<...........<<.<<<<<<..>>>>>>.>>.............<<<<
<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((....
..<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>
>>........<<<<<<<....>>>>>>>.....<<<<<<..>>>>>>..>
>>.................................<<....>>.......
........<<<...>>>.................................
<<<<.<<<<<<..............<......>..........<<<<<<<
.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<........>>>
.......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....
>>>.....>>>>>>>....>>>>>.>>>>>.<<<<........>>>><<<
<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...
........<<<<<..<<<<<...>>>>>...>>>>>.<<<..<<<.....
..>>>...>>>....>>>>>>.>>>>>>..<<.<..<<<<<<<...>>>>
>>>....>.>>..<<<<<<......<.......>...<<<<<<<<<...<
<<.<<.........>>>>>>>>>>>>.>>..<<<<....<<..>>....>
>>>....<<<....>>>...<<<<<<<..<<<<(((.....<<<<<<...
<<.....<<<.<<<<<<<<<........<<<<<.<<<..<<.........
>>..>>>.......<<......>>...>>>>>....>>>>>>>>>>>>.)
)).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>
>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>
>>...>>>>>>>>>...>.....>>>>>><<..............>>...
............<<<.....<<<<<<......>>>>>>..>>>....<.<
<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<..
.<<....<<<<<<<<........>>>>>>>>.....>>.>>>>>.<<<<.
..<<<<<..........>>>>>..>>>>.>>>>....>>>>>>.>.....
.<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>..
....>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>
>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<........
.............<<<<<.<<<.<<<....<<......>>...>>>..>>
>..>>>>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB7ohp Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R18 G19 Y21 S25 F26 K27 R30 Q34 W83 Q96 N97 N101 V119 Q121 E140
Binding residue
(residue number reindexed from 1)		R9 G10 Y12 S16 F17 K18 R21 Q25 W44 Q57 N58 N62 V80 Q82 E86
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0030687 preribosome, large subunit precursor
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ohp, PDBe:7ohp, PDBj:7ohp
PDBsum7ohp
PubMed34813592
UniProtP05740|RL17A_YEAST Large ribosomal subunit protein uL22A (Gene Name=RPL17A)

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