Structure of PDB 7nhk Chain P Binding Site BS01

Receptor Information
>7nhk Chain P (length=134) Species: 1351 (Enterococcus faecalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVPKRVKHRREFRGKMRGEAKGGKEVAFGEWGLQATESHWITNRQIEAAR
IAMTRYMKRGGKVWIKIFPHKSYTSKAIGVRMGKGKGAPEGWVSPVKRGK
IMFEIAGVPEEVAREALRLASHKLPVKTKIVKRE
Ligand information
>7nhk Chain A (length=2905) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaauaguagcgaaguuccugacgucacac
ugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccga
cacagguagucgaggagaguauccuaaggugagcgagcgaacucucguua
aggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuu
cggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacagg
ucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugc
uggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagcc
ccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccu
ugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugu
cucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuac
ccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauug
aguguuuguaccacauguacaggauagguaggagccgaugagaccggaac
gcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacc
cucuaacccgcaccacuaaucguggugggagacagugucagaugggcagu
uugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguuc
ccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcu
ugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugau
ccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccu
ggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuu
ggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaag
gguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgu
cgugagacaguucggucccuauccgucgcgggcguuggaaauuugagagg
agcuguccuuaguacgagaggaccgggauggacuuaccgcugguguacca
guuguucugccaagggcauugcuggguagcuauguagggaagggauaaac
gcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuu
cuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaag
uggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacu
uaacc
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>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
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....>>>>.>>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
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....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<...............>>>>><<<<<<..
..>>>>>>............<<<<<<<<<..<<<.........>>>..<<
<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<
<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>
>>>>>..>>>>><<<<<<.......>>>>>>........<..........
.<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....
>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<
<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<
<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<
....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.
>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>
..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<
<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>
...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))].....
.<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>
>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....
>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..
>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<
<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<
..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<
<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<
<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<
<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<
<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>
>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nhk Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R6 K8 H9 R11 E12 F13 R14 G15 K16 M17 R18 K22 G23 G24 F29 R45 R56 W65 F69 H71 K77 I79 G80 R82 M83 G84 K85 G86 K87 H123 K124 P126 K128
Binding residue
(residue number reindexed from 1)		R5 K7 H8 R10 E11 F12 R13 G14 K15 M16 R17 K21 G22 G23 F28 R44 R55 W64 F68 H70 K76 I78 G79 R81 M82 G83 K84 G85 K86 H122 K123 P125 K127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nhk, PDBe:7nhk, PDBj:7nhk
PDBsum7nhk
PubMed34117249
UniProtA0A1B4XKU1

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