Structure of PDB 7d43 Chain P Binding Site BS01

Receptor Information

>7d43 Chain P (length=421) Species: 9606 (Homo sapiens)

ATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIY
KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHD
ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ
NKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI
VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLK
VGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV
GTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGD
KKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE
KIALSRRVEKHWRLIGWGQIR

Ligand information

>7d43 Chain M (length=16) Species: 9606 (Homo sapiens)

DYTYEELLNRVFNIMR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7d43 ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
• Resolution: 4.3 Å
• Binding residue (original residue number in PDB): D193 L194 P223
• Binding residue (residue number reindexed from 1): D154 L155 P184

Enzymatic activity

• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0008135 translation factor activity, RNA binding
• GO:0016787 hydrolase activity
• GO:0045296 cadherin binding
• GO:1990856 methionyl-initiator methionine tRNA binding

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0002183 cytoplasmic translational initiation
• GO:0006412 translation
• GO:0006413 translational initiation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005850 eukaryotic translation initiation factor 2 complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7d43, PDBe:7d43, PDBj:7d43
• PDBsum: 7d43
• PubMed: 33220178
• UniProt: P41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)