Structure of PDB 7aea Chain P Binding Site BS01

Receptor Information
>7aea Chain P (length=146) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYI
CELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLY
RAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7aea Chain P Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7aea Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C287 C290 F293 C296 P304 C307 Y309 M310
Binding residue
(residue number reindexed from 1)		C117 C120 F123 C126 P134 C137 Y139 M140
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006359 regulation of transcription by RNA polymerase III
GO:0006383 transcription by RNA polymerase III
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7aea, PDBe:7aea, PDBj:7aea
PDBsum7aea
PubMed33558764
UniProtQ9H1D9|RPC6_HUMAN DNA-directed RNA polymerase III subunit RPC6 (Gene Name=POLR3F)

[Back to BioLiP]