Structure of PDB 6tm5 Chain P Binding Site BS01

Receptor Information
>6tm5 Chain P (length=492) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPP
ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLS
GEKKKDDETVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVK
EAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAH
IYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIF
NELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCV
IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQ
AYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRML
VALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQA
AQCYIKYIQDIYSCTAFRYLAQYYFKCKLWDEASTCAQKCCA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6tm5 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R277 Y308 V309 H373 Y399 R400
Binding residue
(residue number reindexed from 1)		R241 Y272 V273 H337 Y363 R364
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007080 mitotic metaphase chromosome alignment
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007096 regulation of exit from mitosis
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tm5, PDBe:6tm5, PDBj:6tm5
PDBsum6tm5
PubMed32307883
UniProtQ9UJX2|CDC23_HUMAN Cell division cycle protein 23 homolog (Gene Name=CDC23)

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