Structure of PDB 6k72 Chain P Binding Site BS01

Receptor Information

>6k72 Chain P (length=421) Species: 9606 (Homo sapiens)

ATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIY
KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHD
ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ
NKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI
VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLK
VGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV
GTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGD
KKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE
KIALSRRVEKHWRLIGWGQIR

Ligand information

>6k72 Chain M (length=16) Species: 9606 (Homo sapiens)

DYTYEELLNRVFNIMR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6k72 Structural basis for eIF2B inhibition in integrated stress response.
• Resolution: 4.6 Å
• Binding residue (original residue number in PDB): K201 Y230 N231
• Binding residue (residue number reindexed from 1): K162 Y191 N192

Enzymatic activity

• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0008135 translation factor activity, RNA binding
• GO:0016787 hydrolase activity
• GO:0045296 cadherin binding
• GO:1990856 methionyl-initiator methionine tRNA binding

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0002183 cytoplasmic translational initiation
• GO:0006412 translation
• GO:0006413 translational initiation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005850 eukaryotic translation initiation factor 2 complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6k72, PDBe:6k72, PDBj:6k72
• PDBsum: 6k72
• PubMed: 31048492
• UniProt: P41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)