Structure of PDB 6exn Chain P Binding Site BS01

Receptor Information

>6exn Chain P (length=73) Species: 559292 (Saccharomyces cerevisiae S288C)

TSHRPQLEARSGAKAAAYTPTGIEHARLLPGHTTLKYRKFSWRKGTAFGR
HKGYINDMTKSEYHQEFLHKHVR

Ligand information

>6exn Chain 2 (length=136)

gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuugua
acauguuacaauaccauuuuuuggcaggacgggaagaggagacgucgcga
cccucgcaggucgcuugauguuucuucuucccguuc

..............................................<<<<
<<<>>>>>>>................<<<<<<<<<<<.<<<<<<<<<<<<
.<<.....>>>>>>..>>>>>>>>.>>>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): H5 R6 P7 L9
• Binding residue (residue number reindexed from 1): H3 R4 P5 L7

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:0045292 mRNA cis splicing, via spliceosome

Cellular Component

• GO:0005634 nucleus
• GO:0005681 spliceosomal complex
• GO:0005684 U2-type spliceosomal complex
• GO:0071013 catalytic step 2 spliceosome

External links

• PDB: RCSB:6exn, PDBe:6exn, PDBj:6exn
• PDBsum: 6exn
• PubMed: 29146871
• UniProt: Q03772|CWC15_YEAST Pre-mRNA-splicing factor CWC15 (Gene Name=CWC15)