Structure of PDB 5sva Chain P Binding Site BS01

Receptor Information
>5sva Chain P (length=487) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSS
VKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKL
QSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSVIFKIRDRTSGQKLLA
IKYGYEDSGSTYKHDRGIANIRNNIESQNLDLIPHGTDFVHSVKKFLRVR
IFTKIESEDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELM
YQIKKECALLISYGVSIENENKVIIELPNEKFEIELLSLDDDSIVNHEQD
LPKINDKRANLMLVMLRLLLVVIFKKTLRSRISSPHGLINLNVDDDILII
RPILGKVRFANYKLLLKKIIKDYVLDIVPGSSITETEVEREQPQENKNID
DENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLMLESPNYCN
ALIHIKFSAGTEANAVSFDVEDFLHFIVAEYIQQKKV
Ligand information
>5sva Chain k (length=25) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PSYSPTSPSYSPTSPSYSPTSPSYS
Receptor-Ligand Complex Structure
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PDB5sva Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.
Resolution15.3 Å
Binding residue
(original residue number in PDB)		S239 S240 M241 P243
Binding residue
(residue number reindexed from 1)		S58 S59 M60 P62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001139 RNA polymerase II complex recruiting activity
GO:0003712 transcription coregulator activity
GO:0005515 protein binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0034605 cellular response to heat
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5sva, PDBe:5sva, PDBj:5sva
PDBsum5sva
PubMed27610567
UniProtP32569|MED17_YEAST Mediator of RNA polymerase II transcription subunit 17 (Gene Name=SRB4)

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