Structure of PDB 5lsp Chain P Binding Site BS01

Receptor Information
>5lsp Chain P (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKV
FPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSEST
MNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGP
MAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTIST
EFAVKLKIDLANRETSIFSYRE
Ligand information
Receptor-Ligand Complex Structure
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PDB5lsp Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
Resolution2.605 Å
Binding residue
(original residue number in PDB)		Y566 F569 T582 C584 T618 N620 T621
Binding residue
(residue number reindexed from 1)		Y48 F51 T64 C66 T100 N102 T103
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5lsp, PDBe:5lsp, PDBj:5lsp
PDBsum5lsp
PubMed28827556
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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