Structure of PDB 5iwa Chain P Binding Site BS01

Receptor Information
>5iwa Chain P (length=85) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLK
VDVERARYWLSVGAQPTDTARRLLRQAGVFRQEAR
Ligand information
>5iwa Chain A (length=1509) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauuggagaguuugauccuggcucagggugaacgcuggcggcgugccua
agacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcg
gacgggugaguaacgcgugggugaccuacccggaagagggggacaacccg
gggaaacucgggcuaaucccccauguggacccgccccuuggggugugucc
aaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugg
ugggguaauggcccaccaaggcgacgacggguagccggucugagaggaug
gccggccacaggggcacugagacacgggccccacuccuacgggaggcagc
aguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuu
ggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccc
ccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgug
ccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugg
gcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacgg
cucaaccgugggggagcgugggauacgcucaggcuagacggugggagagg
gugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaac
gccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaa
agcguggggagcaaaccggauuagauacccggguaguccacgcccuaaac
gaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaa
gcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauuga
cgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcg
aagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugg
ggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucag
cucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgc
cguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaa
agcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccu
gggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaa
cggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaa
cccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccg
cggugaauacguucccgggccuuguacacaccgcccgucacgccauggga
gcgggcucuacccgaagucgccgggagccuacgggcaggcgccgagggua
gggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggug
cggcuggau
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<.
.<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>.
.....<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<
<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>
>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<
<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>.
..>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>
>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..
<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<
<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<..
...<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<
<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<
.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<
<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>....
.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...
.<<<<<<...<<...<<<<.........>>>>...>>>>>>>>.......
...<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....
>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<
<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>
..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>
>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<
<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<
<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<...
.>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>
>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....
>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>
>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<...
<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>
>>>>>>>>...>>.>>>>....>>...>.....<<<<<<<<<....>>>>
>>>>>....
Receptor-Ligand Complex Structure
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PDB5iwa Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		M1 V2 K3 R5 L6 R8 F9 G10 S11 K12 H13 H16 Y17 R18 D23 R25 R26 K27 R28 G30 K31 I33 Y38 P41 R42 K43 T44 W59 V62 G63 Q65 T67 T69 R72 R75 R81 Q82
Binding residue
(residue number reindexed from 1)		M1 V2 K3 R5 L6 R8 F9 G10 S11 K12 H13 H16 Y17 R18 D23 R25 R26 K27 R28 G30 K31 I33 Y38 P41 R42 K43 T44 W59 V62 G63 Q65 T67 T69 R72 R75 R81 Q82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5iwa, PDBe:5iwa, PDBj:5iwa
PDBsum5iwa
PubMed27071098
UniProtQ5SJH3|RS16_THET8 Small ribosomal subunit protein bS16 (Gene Name=rpsP)

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