Structure of PDB 4yhh Chain P Binding Site BS01

Receptor Information
>4yhh Chain P (length=85) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLK
VDVERARYWLSVGAQPTDTARRLLRQAGVFRQEAR
Ligand information
>4yhh Chain A (length=1507) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcgga
cgggugaguaacgcgugggugaccuacccggaagagggggacaacccggg
gaaacucgggcuaaucccccauguggacccgccccuugggguguguccaa
agggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggug
ggguaauggcccaccaaggcgacgacggguagccggucugagaggauggc
cggccacaggggcacugagacacgggccccacuccuacgggaggcagcag
uuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuugg
aggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccccc
gacgaggggacugacgguaccgggguaauagcgccggccaacuccgugcc
agcagccgcgguaauacggagggcgcgagcguuacccggauucacugggc
guaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcu
caaccgugggggagcgugggauacgcucaggcuagacggugggagagggu
gguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgc
cgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaag
cguggggagcaaaccggauuagauacccggguaguccacgcccuaaacga
ugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagc
gcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacg
ggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaa
gaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggg
ugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcu
cgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccg
uuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaag
cgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugg
gcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacg
gggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacc
cgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcg
gugaauacguucccgggccuuguacacaccgcccgucacgccaugggagc
gggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagg
gcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcg
gcuggau
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>...
...<<..<....<<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<
....>>>>>>......>>>>....<<<<.<<<<<....>>>>>.>>>>..
.<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<
<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...
>>>>>>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>
>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<
<<......<<<<....>>>>.....>>>>....<<<<<........<<<<
.....>>>>..........>>>>>......<<<<<(((...<<<<<....
.<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<
((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<..
...>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<
<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>.....
.....<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<
<<<<<...<<...<<<<.........>>>>...>>>>>>>>.........
.<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>
>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<
.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..
........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>.
..<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<
<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<
<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>
>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>
...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>
>>..>>....>>>.....>>>>>>>......<....<<<<<<<.......
.>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>
>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<
<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>
>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>
>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4yhh Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.
Resolution3.417 Å
Binding residue
(original residue number in PDB)		M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 H16 Y17 R18 D23 R25 R26 K27 R28 K31 Y32 K35 Y38 P41 R42 K43 T44 T45 V62 G63 T67 D68 T69 R72 R75 F80 R81 Q82
Binding residue
(residue number reindexed from 1)		M1 V2 K3 R5 L6 R8 F9 S11 K12 H13 H16 Y17 R18 D23 R25 R26 K27 R28 K31 Y32 K35 Y38 P41 R42 K43 T44 T45 V62 G63 T67 D68 T69 R72 R75 F80 R81 Q82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4yhh, PDBe:4yhh, PDBj:4yhh
PDBsum4yhh
PubMed25753625
UniProtQ5SJH3|RS16_THET8 Small ribosomal subunit protein bS16 (Gene Name=rpsP)

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