Structure of PDB 4crm Chain P Binding Site BS01

Receptor Information
>4crm Chain P (length=608) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSDKNSRIAIVSADKCKPKKCRQECKRSCPVVKTGKLCIEVTPTSKIAFI
SEILCIGCGICVKKCPFDAIQIINLPTNLEAHVTHRYSANSFKLHRLPTP
RPGQVLGLVGTNGIGKSTALKILAGKQKPNLGRFDDPPEWQEIIKYFRGS
ELQNYFTKMLEDDIKAIIKPQYVDNIPRAIKGPVQKVGELLKLRMEKSPE
DVKRYIKILQLENVLKRDIEKLSGGELQRFAIGMSCVQEADVYMFDEPSS
YLDVKQRLNAAQIIRSLLAPTKYVICVEHDLSVLDYLSDFVCIIYGVPSV
YGVVTLPASVREGINIFLDGHIPAENLRFRTEALQFRIADATEDLQNDSA
SRAFSYPSLKKTQGDFVLNVEEGEFSDSEILVMMGENGTGKTTLIKLLAG
ALKPDEGQDIPKLNVSMKPQKIAPKFPGTVRQLFFKKIRGQFLNPQFQTD
VVKPLRIDDIIDQEVQHLSGGELQRVAIVLALGIPADIYLIDEPSAYLDS
EQRIICSKVIRRFILHNKKTAFIVEHDFIMATYLADKVIVFEGIPSKNAH
ARAPESLLTGCNRFLKNLNVTFRRDPNSFRPRINKLDSQMDKEQKSSGNY
FFLDNTGI
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain4crm Chain P Residue 1609 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4crm Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1.
Resolution8.75 Å
Binding residue
(original residue number in PDB)		Y87 F92 N112 G113 I114 G115 K116 S117 T118 S299
Binding residue
(residue number reindexed from 1)		Y87 F92 N112 G113 I114 G115 K116 S117 T118 S299
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006415 translational termination
GO:0032790 ribosome disassembly
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4crm, PDBe:4crm, PDBj:4crm
PDBsum4crm
PubMed25001285
UniProtQ03195|RLI1_YEAST Translation initiation factor RLI1 (Gene Name=RLI1)

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