Structure of PDB 3irw Chain P Binding Site BS01

Receptor Information
>3irw Chain P (length=90) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPNHTIYINNLNEKIKKDELKKSLHAIFSRFGQILDILVSRSLKMRGQAF
VIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAK
Ligand information
>3irw Chain R (length=91) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucacgcacagggcaaaccauucgaaagagugggacgcaaagccuccgg
ccuaaaccauugcacuccgguagguagcgggguuaccgaug
...<<<.......<<...<<<<<<....>>>>>>...>>...<<<.<<<<
<<<..<<<..........>>>>>>>..>>>>>>....>.>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3irw Structural basis of ligand binding by a c-di-GMP riboswitch.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y13 N15 N16 E19 K20 S48 L49 K50 M51 R52 G53 Q54 F56 Q85 Y86 K88 D90 S91 D92
Binding residue
(residue number reindexed from 1)		Y7 N9 N10 E13 K14 S42 L43 K44 M45 R46 G47 Q48 F50 Q79 Y80 K82 D84 S85 D86
Binding affinityPDBbind-CN: Kd=10pM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:3irw, PDBe:3irw, PDBj:3irw
PDBsum3irw
PubMed19898477
UniProtP09012|SNRPA_HUMAN U1 small nuclear ribonucleoprotein A (Gene Name=SNRPA)

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