Structure of PDB 3d48 Chain P Binding Site BS01

Receptor Information
>3d48 Chain P (length=165) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTLRDLFDRAVVLSHYIHNLSSEMFSEFDKGFITKAINSCHTSSLATPED
KEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRAILSKAVEIEEQTKR
LLERMELIVSQVIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKID
NYLKLLKCRIIHNNN
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain3d48 Chain P Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3d48 Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S57 H59 L171 C174
Binding residue
(residue number reindexed from 1)		S39 H41 L138 C141
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005148 prolactin receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0016525 negative regulation of angiogenesis
GO:0030879 mammary gland development
GO:0031667 response to nutrient levels
GO:0038161 prolactin signaling pathway
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:1902895 positive regulation of miRNA transcription
GO:1903489 positive regulation of lactation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031904 endosome lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3d48, PDBe:3d48, PDBj:3d48
PDBsum3d48
PubMed18467331
UniProtP01236|PRL_HUMAN Prolactin (Gene Name=PRL)

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