Structure of PDB 1svc Chain P Binding Site BS01

Receptor Information
>1svc Chain P (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PYLQILEQPKQRGFRFRYVAEGPSHGGLPGASSEKNKKSYPQVKICNYVG
PAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGI
LHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDR
EKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYD
SKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENG
GVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLET
SEPKPFLYYPE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1svc Structure of the NF-kappa B p50 homodimer bound to DNA.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R57 Y60 E63 T146 K147 R308 Q309
Binding residue
(residue number reindexed from 1)		R15 Y18 E21 T104 K105 R266 Q267
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1svc, PDBe:1svc, PDBj:1svc
PDBsum1svc
PubMed7830764
UniProtP19838|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (Gene Name=NFKB1)

[Back to BioLiP]