Structure of PDB 1h71 Chain P Binding Site BS01

Receptor Information

>1h71 Chain P (length=455) Species: 76981 (Pseudomonas sp. 'TAC II 18')

GTSSAFTQIDNFSHFYDRGDHLVNGKPSFTVDQVADQLTRSGASWHDLNN
DGVINLTYTFLTAPPVGYASRGLGTFSQFSALQKEQAKLSLESWADVAKV
TFTEGPAAGDDGHQTFANFSASNGGAAFAYLPNSSRKGESWYLINKDYQV
NKTPGEGNYGRQTLTHEIGHTLGLSHPGDYNPTYRDAVYAEDTRAYSVMS
YWSEKNTGQVFTKTGEGAYASAPLLDDIAAVQKLYGANLETRADDTVYGF
NSTADRDFYSATSSTDKLIFSVWDGGGNDTLDFSGFSQNQKINLTAGSFS
DVGGMTGNVSIAQGVTIENAIGGSGNDLLIGNDAANVLKGGAGNDIIYGG
GGADVLWGGTGSDTFVFGAVSDSTPKAADIIKDFQSGFDKIDLTAITKLG
GLNFVDAFTGHAGDAIVSYHQASNAGSLQVDFSGQGVADFLVTTVGQVAT
YDIVA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1h71 Chain P Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1h71 Crystal Structures of a Psychrophilic Metalloprotease Reveal New Insights Into Catalysis by Cold-Adapted Proteases
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): D49 N51 D53 V55 N57 D114
• Binding residue (residue number reindexed from 1): D47 N49 D51 V53 N55 D111
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.40: serralysin.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1h71, PDBe:1h71, PDBj:1h71
• PDBsum: 1h71
• PubMed: 12577270
• UniProt: O69771