Structure of PDB 1e49 Chain P Binding Site BS01

Receptor Information
>1e49 Chain P (length=206) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MERNKLARQIIDTCLEMTRLGLNQGTAGLVSVRYQDGMLITPTGIPYEKL
TESHIVFIDGNGKHEEGKLPASEWRFHMAAYQSRPDANAVVHNHAVHCTA
VSILNRSIPAIHYMIAAAGGNSIPCAPYATFGTRELSEHVALALKNRKAT
LLQHHGLIACEVNLEKALWLAHEVEVLAQLYLTTLAITDPVPVLSDEEIA
VVLEKF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1e49 Chain P Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1e49 Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
Resolution2.53 Å
Binding residue
(original residue number in PDB)		E73 H92 H94 H155
Binding residue
(residue number reindexed from 1)		E73 H92 H94 H155
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.2.17: L-fuculose-phosphate aldolase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008738 L-fuculose-phosphate aldolase activity
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006004 fucose metabolic process
GO:0019317 fucose catabolic process
GO:0019323 pentose catabolic process
GO:0019568 arabinose catabolic process
GO:0019571 D-arabinose catabolic process
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1e49, PDBe:1e49, PDBj:1e49
PDBsum1e49
PubMed11054289
UniProtP0AB87|FUCA_ECOLI L-fuculose phosphate aldolase (Gene Name=fucA)

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