Structure of PDB 8p4e Chain O Binding Site BS01

Receptor Information
>8p4e Chain O (length=695) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEF
CGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWR
KKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPE
NISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLM
ALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANS
ERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDH
EFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWG
IPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFD
YRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVE
IVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAV
SKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDD
RHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAP
FHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA
Ligand information
>8p4e Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggacauacauaaagaccaggc
.....................
Receptor-Ligand Complex Structure
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PDB8p4e Structural insights into human co-transcriptional capping.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K203 S204 D207 M214 R218 E373 A438 N439
Binding residue
(residue number reindexed from 1)		K63 S64 D67 M74 R78 E233 A298 N299
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0006397 mRNA processing
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p4e, PDBe:8p4e, PDBj:8p4e
PDBsum8p4e
PubMed37369200
UniProtQ8N1G2|CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Gene Name=CMTR1)

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