Structure of PDB 8oeq Chain O Binding Site BS01

Receptor Information
>8oeq Chain O (length=116) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEDALKVVLRTSLVHDGLARGLREASKALSKREAQLCVLCDSVTEESIIK
LVEALCNEPEEKIPLIKVSDAKLLGEWAGLCQLDRDGNARKVVGASCVVV
KNWGADSDERNILLEH
Ligand information
>8oeq Chain B (length=1712) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaa
uucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguau
uuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaa
cuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucug
cccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggg
uaacggggaauaaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacgg
ggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguac
aauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguua
aaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagc
cgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggac
guuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucggggguaucaguauucaguugucagaggugaaauucuuggauu
uacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacg
caaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcug
guauagucacuucuuagagggacuaucgauuucaagucgauggaaguuug
aggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcg
cuacacugacggagccagcgaguauaagccuuggccgagaggucugggaa
aucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcuc
uucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuac
gucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcu
uagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuug
gucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..........<<.....<..<<....
...>>..>......>>........<<<<<..<<....>>..>>>>><...
<<<<<<.......((((((.<<<....>>>..............>>>>>>
.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>
.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.
>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>
>..>>>..>....>.>.....<<<<...<...>...>>>>......<<..
<...........>..>>.........<<<<<((......<<<<.....<<
..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.
....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>
>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<...
....>..<<<....>>>....>>......>>.>>..>>>.........<<
<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>
>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......
<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<
<..<<<.<<<<<<......<<........>>..........<<<<<....
..<<<<<........<<.<<<........>>>.>>......>>>>>...<
<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>
>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>..
..>>.......>>>>>>>...........<<<<<<..........>>>>>
>..........>>>>>>....<<<<<<<<.......>>>>>>>>......
>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<
.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>
>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)
R43 L45 R46 E47 T67 L103 K114 G117 A118 S119
Binding residue
(residue number reindexed from 1)
R20 L22 R23 E24 T44 L80 K91 G94 A95 S96
External links