Structure of PDB 8ihl Chain O Binding Site BS01

Receptor Information

>8ihl Chain O (length=97) Species: 9606 (Homo sapiens)

KTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILE
LAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNI

Ligand information

>8ihl Chain I (length=353)

atcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctag
caccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaagg
ggattactccctagtctccaggctcgagctcaattggtcgtagacagctc
tagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgcca
aggggattactccctagtctccaggctcgagctcaattggtcgtagacag
ctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccg
ccaaggggattactccctagtctccaggcacgtgtcagatatatacatcc
gat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ihl Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties.
• Resolution: 7.64 Å
• Binding residue (original residue number in PDB): R35 V43 G44 A45 K75 T76
• Binding residue (residue number reindexed from 1): R21 V29 G30 A31 K61 T62

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0008285 negative regulation of cell population proliferation
• GO:0031507 heterochromatin formation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8ihl, PDBe:8ihl, PDBj:8ihl
• PDBsum: 8ihl
• PubMed: 38191828
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)