Structure of PDB 8g8n Chain O Binding Site BS01

Receptor Information

>8g8n Chain O (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QVQLVQSGAEVKKPGSSVKVSCKASGYTFTNYFMNWVRQAPGQGLEWMGR
VDPEQGRADYAEKFKKRVTITADKSTSTAYMELSSLRSEDTAVYYCARRA
MDNYGFAYWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN
HKPSNTKVDKKVEPKSC

Ligand information

>8g8n Chain R (length=9) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

CPGKGLPSC

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8g8n XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	F33 R50 R99 Y104
Binding residue (residue number reindexed from 1)	F33 R50 R99 Y104

External links

PDB	RCSB:8g8n, PDBe:8g8n, PDBj:8g8n
PDBsum	8g8n
PubMed	38164757

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