Structure of PDB 8fvy Chain O Binding Site BS01

Receptor Information
>8fvy Chain O (length=139) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YAPENLPAKNNNSEAFAVCHIYAGKNDTFIHVTDLSGRETIGRVSGGMKV
KRHCDEPSAYAAMQATQDLIEIITDRGITAVHIKIRADGGTGKRVYGQGG
SAAIRALVRGGIKIGRIEDSTPIPTDRTRHKGGRRGRRL
Ligand information
>8fvy Chain 2 (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcac
cccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacg
ugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggccc
gcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgag
ggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccug
cgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaa
ugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggccca
cagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaa
uuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccgua
guuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccgu
uggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagcc
ccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaaca
ggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgcc
ucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccac
cguauucccggccguaaacggugccgccccgcggccggcgcgcgcguccc
gccggccgcccagggaaaccgggaggcuccgggcucuggggggaguaugg
ccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacgug
gagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggac
gcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcggugg
ugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgaca
acgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcggg
aggacggcggggcgauagcaggucugugaugcccucagacgcccugggcc
gcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcgg
agcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagg
aaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccc
cuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgc
cccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagu
cguaacaagguauccguaggugaaccugcggauggaucccu
...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<.<<<.........>>>>>......<<........<<<..<<..
<<...<<<<..........<<.....<<<<<<....>>>>>>......>>
.....<<....<<<...(((..<.....>..>>>...>>.........>>
>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>
>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<...
.......>>>>>>.<.<<....>>.>...>>>>>>.........<<<...
.<<<<...>>>>..>>>..>...>>>>>............<<<<<<....
.....>>>>>>.....<<<<<((....<<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...
<<<.......<<<.<<<<<<.<.....<<..<<.......>>........
....>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>....
......<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.
>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.
>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>
>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>
>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<
<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<..<<<<<.
.<<<.<<<<<<......<<........>>.........<<<<<.<....<
<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<
<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....
>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>
........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...
>>.>>>>.>>>.....<<<<<<<.....<.<<<.<<....>>.>>>..>.
...>>>>>>>......<....<<.<<<<......>>>>.>>....>....
.>>>>>.....<<<<<.<<.......>>.>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.
<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.
>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fvy The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function
Resolution2.94 Å
Binding residue
(original residue number in PDB)		K31 N32 D33 F35 H37 G43 R44 T46 R49 S51 G53 H59 I129 P130 T131 D132 R135 K137 R140 R141 R143 R144 L145
Binding residue
(residue number reindexed from 1)		K25 N26 D27 F29 H31 G37 R38 T40 R43 S45 G47 H53 I123 P124 T125 D126 R129 K131 R134 R135 R137 R138 L139
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fvy, PDBe:8fvy, PDBj:8fvy
PDBsum8fvy
PubMed38242118
UniProtE2RU83

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