Structure of PDB 8e5t Chain O Binding Site BS01

Receptor Information
>8e5t Chain O (length=183) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPVVVIDGKGHLVGRLASVVAKQLLNGQKIVVVRAEELNISGEFFRNKL
KYHDFLFRAPSRIFYKALRGMVSHKTARGKAALERLKVFEGIPPPYDKKK
RVVVPQALRVLRLKPGRKYTTLGKLSTSVGWKYEDVVAKLEAKRKVSSAE
YYAKKRAFTKKVASANATAAESDVAKQLAALGY
Ligand information
>8e5t Chain 1 (length=743) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaaaagcggaggaaaaga
aaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaa
auuugaaaucugguacggugcccgaguuguaauuuggagagggcaacuug
uaaagugccuucgaagagucgaguuguuuugcagcucuaaguggguggua
aauuccaucuaaagcuaaauauuggcgagagacuuugaaaagagaguaaa
uuguugaaagggaagggcauuugaucagacauggugucacugggccagca
ucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaa
guauuauagccugugggaauacugccagcugggacugaggacugcgacgu
aagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacg
gaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacg
cguagguuggggccucgcaagaggugcacaaucgaccgugaguaagagca
uagcuguugggaguuccugccgaaguagaguuaaggugccggaauacacg
cucaucagaggcgcucaagcguguuaccuauacucuaccgucaggguuga
uaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuag
accguaaggucgggucgaacggccucuagugcagaucuuggug
..........................<<<<<<....>>>>>.>...<...
..<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<
........<<.<<<<<.>>>>>.>>........>....<<<<<<<.<<..
...>>>>>>>>>........<<<<<<<...>>>>>>>.....<<<<<<..
....>>>>>>..>>>....>............<<<<....>>>>......
...............<<<<<.<<<<<<..<..<<<<.>>>>.><<<<<<<
.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>
>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<..
..>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>
><<<<<<<...<<<<<<.<<<<<<..<<<<.<<<<<.....>>>>>.>>>
>...<<<<<..<<<<<....>>>>>...>>>>>.<<.....>>....>>>
>>>.>>>>>>..<<.<<<<<<...<<<<<<<..<<<<(((.....<<<<<
<.....<<.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<...
......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<
<<<....>>>>>>>>...>>>>>>>>>>..>>...>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e5t A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		L15 G17 R18 S21 L28 S44 A83 M87 K91 Q122 V126 L127 R128 L129 K130 R133
Binding residue
(residue number reindexed from 1)		L13 G15 R16 S19 L26 S42 A67 M71 K75 Q106 V110 L111 R112 L113 K114 R117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000470 maturation of LSU-rRNA
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e5t, PDBe:8e5t, PDBj:8e5t
PDBsum8e5t
PubMed37037974
UniProtP26784|RL16A_YEAST Large ribosomal subunit protein uL13A (Gene Name=RPL16A)

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