Structure of PDB 7y7g Chain O Binding Site BS01

Receptor Information

>7y7g Chain O (length=88) Species: 562 (Escherichia coli)

SLSTEATAKIVSEFGRDANDTGSTEVQVALLTAQINHLQGHFAEHKKDHH
SRRGLLRMVSQRRKLLDYLKRKDVARYTQLIERLGLRR

Ligand information

>7y7g Chain A (length=1520)

aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacg
aguggcggacgggugaguaaugucugggaaacugccugauggagggggau
aacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagag
ggggccucuugccaucggaugugcccagaugggauuagcuaguagguggg
guaacggcucaccuaggcgacgaucccuagcuggucugagaggaugacca
gccacacuggaacugagacacgguccagacuccuacgggaggcagcagug
gggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguau
gaagaaggccuucggguuguaaaguacuuucagcggggaggaagggagua
aaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcua
acuccgugccagcagccgcgguaauacggagggugcaagcguuaaucgga
auuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaa
uccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucu
cguagagggggguagaauuccagguguagcggugaaaugcguagagaucu
ggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcuca
ggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacg
ccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcua
acgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaa
augaauugacgggggcccgcacaagcgguggagcaugugguuuaauucga
ugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucaga
gaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucg
ucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaaccc
uuauccuuuguugccagcgguccggccgggaacucaaaggagacugccag
ugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuac
gaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccu
cgcgagagcaagcggaccucauaaagugcgucguaguccggauuggaguc
ugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaau
gccacggugaauacguucccgggccuuguacacaccgcccgucacaccau
gggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuu
accacuuugugauucaugacuggggugaagucguaacaagguaaccguag
gggaaccugcgguuggauca

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>.
.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<...
..<<<<<......>>>>>......>>.>.....<<<....>>>....<<<
<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.
........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>
.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<
<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((..
.<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>...
.......<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....
..<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<
<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>
>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..
.>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>
>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..
))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..
)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<.
.......>>..........<<<<<<<......<<<<<<<..<<<<<<<..
..>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<....
...<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<
<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<
<.....>>>>>........>>>>.........>>>...>>>>>>>>>...
>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<
<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<
........>>>>>>>....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<
<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>
>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<
<....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7g Glycosylation of queuosine in tRNAs contributes to optimal translation and post-embryonic growth in vertebrates (Under submission)
• Resolution: 2.34 Å
• Binding residue (original residue number in PDB): D21 T22 G23 Q28 L39 H42 H46 K48 D49 H51 S52 R54 R58 Q62 K65 Y69
• Binding residue (residue number reindexed from 1): D20 T21 G22 Q27 L38 H41 H45 K47 D48 H50 S51 R53 R57 Q61 K64 Y68

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0070181 small ribosomal subunit rRNA binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006417 regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7y7g, PDBe:7y7g, PDBj:7y7g
• PDBsum: 7y7g
• PubMed: 37992713
• UniProt: P0ADZ4|RS15_ECOLI Small ribosomal subunit protein uS15 (Gene Name=rpsO)