Structure of PDB 7wtw Chain O Binding Site BS01

Receptor Information
>7wtw Chain O (length=135) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADR
DESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSAL
RALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
Ligand information
>7wtw Chain 2 (length=1586) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgauaccgucguaguuccgaccaua
aacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggc
agcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaa
agcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcuuaauuugcacccggcccgacacggacaggauugacagauugaua
gcucuuucucgauuccgugggugguggugcauggccguuguuggcugguu
aauuccgaugaacgagacucuggcaugcuauucuuagagggacaaguggc
guucagccacccgagauugagcuaacaggucugugaugcccuguccgggg
cugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcg
cggguaacccguugaaccccauucgugauggggaucggggauugcaauua
uuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguu
gauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauugg
augguuuagugaggcccucggaucggccccgccggggugcccuggcggag
cgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgagg
uuuccguaggugaaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<....>>>>...>>>>>>>>....
......<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>.
.>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....
>>>>....>>>..)))).]]....<<<<<<<<..<<..<<<<<.<<<<.<
<<<<<..........<<<<<.....<<<<<<.......<<.<<<......
..>>>.>>.....>>>>>>......<<<.<<.<<<<<<.<<<...<<<..
....>>>...>>>....<<<...<...<<<....>>>..>.....<<<<<
.....>>>>>........>>>...>>.>>>>..>>..>>>....>>>>>.
..>>.>>>>.>>>.>...<<.<<<........<.<<<.<<<<....>>>>
.>>>....>.........>>>.>>......<.....<<<<<.........
.>>>>>.....>.....>>>>>.....<<<<<<<<<.....>>>>>>>>>
......>>...>>>>>>>>......<<<...<<....<<<<.<<....<<
<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>
.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>
><<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wtw The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H32 F34 F37 N38 D39 F41 H43 G49 K50 E51 T52 R55 T57 G59 M60 D65 R66 E68 R98 I135 P136 S137 D138 T140 R141 R142 K143 R146 R147 L151
Binding residue
(residue number reindexed from 1)		H16 F18 F21 N22 D23 F25 H27 G33 K34 E35 T36 R39 T41 G43 M44 D49 R50 E52 R82 I119 P120 S121 D122 T124 R125 R126 K127 R130 R131 L135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtw, PDBe:7wtw, PDBj:7wtw
PDBsum7wtw
PubMed36321656
UniProtP62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)

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