Structure of PDB 7tz6 Chain O Binding Site BS01

Receptor Information
>7tz6 Chain O (length=423) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPPHPQDLEFTRLPNGLVIASLENYAPASRIGLFIKAGSRYENSNNLGTS
HLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTRENMAYTVECLRDDV
DILMEFLLNVTTAPEFRRWEVAALQPQLRIDKAVALQNPQAHVIENLHAA
AYRNALANSLYCPDYRIGKVTPVELHDYVQNHFTSARMALIGLGVSHPVL
KQVAEQFLNIRGGLGLSGAKAKYHGGEIREQNGDSLVHAALVAESAAIGS
AEANAFSVLQHVLGAGPHVKRGSNATSSLYQAVAKGVHQPFDVSAFNASY
SDSGLFGFYTISQAASAGDVIKAAYNQVKTIAQGNLSNPDVQAAKNKLKA
GYLMSVESSEGFLDEVGSQALAAGSYTPPSTVLQQIDAVADADVINAAKK
FVSGRKSMAASGNLGHTPFIDEL
Ligand information
Receptor-Ligand Complex Structure
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PDB7tz6 Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc 1 complexes.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		R70 L71 E90 K95 L96 S97 V98 T99 S100 Q156 I160 D308 S310 F312 N313 A314 Y325
Binding residue
(residue number reindexed from 1)		R54 L55 E74 K79 L80 S81 V82 T83 S84 Q140 I144 D292 S294 F296 N297 A298 Y309
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tz6, PDBe:7tz6, PDBj:7tz6
PDBsum7tz6
PubMed37236355
UniProtP23004|QCR2_BOVIN Cytochrome b-c1 complex subunit 2, mitochondrial (Gene Name=UQCRC2)

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