Structure of PDB 7pwf Chain O Binding Site BS01

Receptor Information
>7pwf Chain O (length=126) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAFAVCHIYAGKNDTFIHVTDLSGRETIGRVSGGMKVKRHCDEPSAYAAM
QATQDLIEIITDRGITAVHIKIRADGGTGKRVYGQGGSAAIRALVRGGIK
IGRIEDSTPIPTDRTRHKGGRRGRRL
Ligand information
>7pwf Chain 2 (length=1355) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccggucgauccugccggagcgcgacgcucuccccaaggacgaagccau
gcaugccucaggacgcggcggacggcucaggacaacgguugcaccccccg
uggcggucgccggacaccgcuggcaacccggcgccaagacgugcgcgcaa
gggcgggccccgggcgagcagcgugacgcagcgacggcccgcccgggcuu
ccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgc
cuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcc
cgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgc
gcggcggcgcgacggggugcgcgcgagucaggcgggcccaccccgacccg
ccagggcaaggcuggugccagcagccgcgguaauuccagcucggcgagcg
ucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgcc
acgaggaaacgggagcgcuccaggcagguuggacccgccgcgugggaccg
cggcgggcccggcgcgccgcggcagccccgaggagagcgggcgggggcac
cgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccg
gccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggcc
gggggcuagaaggcgaucagacaccaccguauucccggccguaaacggug
ccgccccgcggccggcgcgcgucccgccggccgcccagggaaaccgggag
gcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcau
ugacggagggguacaccagacguggagucugcggcucaaucugacucaac
gcgcgcaccucaccaggcccgcgcgguggugcauggccgcucccagcccg
uggcgcgagccgugcuccauugcgacaacgagcgagaccccggccgcggg
ccgcgggacggcccgcagcgggaggacggcggggcgauagcaggucugug
augcccuccgcccugggccgcacgcgcgcuacacuggcggggccagccgg
cgcccgcgaggacgcgagcccccgccguggccgggaccgcgggcuggaac
gcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgcc
ggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugg
gcgcugcggcgagcgccccggacgggaagggccgcgagccccagcgccug
gaggaaggagaagucguaacaagguauccguaggugaaccugcggaugga
ucccu
..<<<<<.[..(((>>>>>.<<<<<<<<<..<<<....<......<<<.<
<<..<<<.........>>>......<<........<<<..<<..<<...<
<<<<......<<.....<<<<<<....>>>>>>......>>.....<<..
..<<<....[..<.....>..>>>...>>.......>.>>>>..>>>>..
>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>
>>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<...>>>
..>>>..>.....>>>..........<<<.<<.........>>.>>>..<
<<.<(((...<<<<<.....<<.)))>>.......>>>>>>.>>>..>>>
>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<
<<<.......<<..<<.......>>........>>.....>>>>>..>.>
>><<.<<<...]...>>>...>>..........<<<<<<<.....<<<<.
.<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>....
...<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<
<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<
<<.<<..<<<<<<<<<<.<...>.>>>>>>>>>>...<<..))>>....>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]
<<<<<.<<<<<<<.<<.<<<<<<..<<<.<<<<<<......<<.......
.>>.........<<<<<.<.....<<.<<<..<<.<<<<<<....<<.<<
<<<<....>>>..<<......>>....>>>.>>....<<<<<.<<<<<<.
>>>>>>.....<<<<<.>>>>>.......>>>>>....>>>.>>>.....
>>>>>>>..>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<
<<.<<....>>.>>>....>>>>>>>......<....<<.<<<<......
>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<
<<<<<<.<<<..<<<.<<<.........>>>.>>>..>>>.>>>>>>>>.
..>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>...
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pwf Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		N32 D33 F35 H37 G43 R44 T46 R49 S51 G53 H59 C60 E62 R92 I129 P130 T131 D132 T134 R135 G139 R140 R141 R143 R144 L145
Binding residue
(residue number reindexed from 1)		N13 D14 F16 H18 G24 R25 T27 R30 S32 G34 H40 C41 E43 R73 I110 P111 T112 D113 T115 R116 G120 R121 R122 R124 R125 L126
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwf, PDBe:7pwf, PDBj:7pwf
PDBsum7pwf
PubMed35100413
UniProtE2RU83

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