Structure of PDB 7of4 Chain O Binding Site BS01

Receptor Information

>7of4 Chain O (length=152) Species: 9606 (Homo sapiens)

ISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEK
LIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRML
QIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQ
SQ

Ligand information

>7of4 Chain A (length=1463)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacgu
uuaacggccgcgguaccgugcaaagguagcauaaucacuuguuccuuaaa
uagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuu
aaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaaga
cgagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaa
aaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguac
augcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuug
accaacggaacaaguuacccuagggauaacagcgcaauccuauucuagag
uccauaucaacaauaggguuuacgaccucgauguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
aauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaag
cgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacc
caagaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<..<<<<<..>>
>..>>>>><<<<<..>>>>>........<...........<<<<<<....
.>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>
>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<
.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
..<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>
............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.
......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.>...>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>..
.<<<.<<<.................>>>.>>><<<<<...<<<....>>>
.>>>>>......<<<................>>>.............<<<
<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of4 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): I9 S10 H11 G12 R13 V14 R16 R17 L20 G21 H27 R30 N31 L32 H39 I42 A47 R48 T81 E82 D116 R117 A118 K119
• Binding residue (residue number reindexed from 1): I1 S2 H3 G4 R5 V6 R8 R9 L12 G13 H19 R22 N23 L24 H31 I34 A39 R40 T73 E74 D108 R109 A110 K111

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of4, PDBe:7of4, PDBj:7of4
• PDBsum: 7of4
• PubMed: 34135319
• UniProt: Q9NRX2|RM17_HUMAN Large ribosomal subunit protein bL17m (Gene Name=MRPL17)