Structure of PDB 7nhk Chain O Binding Site BS01 |
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| >7nhk Chain A (length=2905)
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uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaauaguagcgaaguuccugacgucacac
ugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccga
cacagguagucgaggagaguauccuaaggugagcgagcgaacucucguua
aggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuu
cggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacagg
ucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugc
uggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagcc
ccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccu
ugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugu
cucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuac
ccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauug
aguguuuguaccacauguacaggauagguaggagccgaugagaccggaac
gcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacc
cucuaacccgcaccacuaaucguggugggagacagugucagaugggcagu
uugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguuc
ccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcu
ugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugau
ccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccu
ggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuu
ggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaag
gguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgu
cgugagacaguucggucccuauccgucgcgggcguuggaaauuugagagg
agcuguccuuaguacgagaggaccgggauggacuuaccgcugguguacca
guuguucugccaagggcauugcuggguagcuauguagggaagggauaaac
gcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuu
cuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaag
uggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacu
uaacc |
.<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<
..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<<..>>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<
<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((..
....<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>
>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<....
....>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>
...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>
>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<.....
.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>
>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<..
.<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.
....>>>>.>>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<<<...
......>>>...>>.........<<......>>...>>>>>....>>>>>
>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<
<<<<....>>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.
<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>>.......<<
....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<..
.<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>.
..>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......
<<...<<<<....<<<<..<<...<<<.<.<<<<<<...(((....>>>>
>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>
..>>>>>...>>...<<............>>.....>>>>....>>...>
>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<..
....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<...............>>>>><<<<<<..
..>>>>>>............<<<<<<<<<..<<<.........>>>..<<
<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<
<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>
>>>>>..>>>>><<<<<<.......>>>>>>........<..........
.<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....
>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<
<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<
<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<
....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.
>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>
..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<
<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>
...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))].....
.<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>
>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....
>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..
>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<
<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<
..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<
<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<
<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<
<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<
<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>
>>... |
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| PDB | 7nhk Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. |
| Resolution | 2.9 Å |
Binding residue
(original residue number in PDB) | H4 L6 E10 G11 S12 R13 Q14 R16 R18 V19 G20 R21 G22 S24 K29 T30 A31 G32 R33 G34 Q35 K36 Q38 K39 R41 S42 G43 R47 F50 E51 G52 G53 Q54 T55 F58 R59 R60 L61 P62 K63 R64 G65 F66 T67 N68 I69 R71 N78 R84 K103 K110 L112 A113 S131 |
Binding residue
(residue number reindexed from 1) | H4 L6 E10 G11 S12 R13 Q14 R16 R18 V19 G20 R21 G22 S24 K29 T30 A31 G32 R33 G34 Q35 K36 Q38 K39 R41 S42 G43 R47 F50 E51 G52 G53 Q54 T55 F58 R59 R60 L61 P62 K63 R64 G65 F66 T67 N68 I69 R71 N78 R84 K103 K110 L112 A113 S131 |
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| Enzyme Commision number |
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